@article { author = {Hayat, EL Ouafy and Aamor, Mouna and Mustapha, Oubenali and Mohamed, Mbarki and EL Haimouti, Aziz and Tarik, EL Ouafy}, title = {Simultaneous Electrochemical Analysis of Ibuprofen and Paracetamol by Clay Modified Carbon Paste Electrode: Analytical Application in Human Blood}, journal = {Analytical and Bioanalytical Electrochemistry}, volume = {14}, number = {1}, pages = {18-31}, year = {2022}, publisher = {Analytical and Bioanalytical Electrochemistry is an international scientific journal, which is published online every 3 months (since 2009), every 2 months (since 2011) and monthly (since 2018) by Center of Excellence in Electrochemistry, University of Tehran}, issn = {-}, eissn = {2008-4226}, doi = {}, abstract = {Cyclic voltammetry and differential pulse voltammetry techniques for the simultaneous analysis of ibuprofen (IBU) and paracetamol (PCT) at carbon paste electrode modified with clay (CPE-Clay) are reported. The surface characterization of the clay was realized by zero-point charge and electrochemical methods. The electrocatalytic activity of clay toward ibuprofen electro-oxidation and paracetamol redox were reported. The kinetic parameters for ibuprofen and paracetamol electro-analysis by the modified carbon paste electrode clay-CPE were calculated. Peak ibuprofen oxidation and peaks paracetamol redox were well presented onto modified electrode clay-CPE when compared with other electrodes in the literature.  Peak oxidation of the ibuprofen and peaks paracetamol redox was well presented onto modified electrode clay-CPE compared with other electrodes in the literature. The high sensitivity of the clay-CPE is measured by the DPV method showed linear variation with ibuprofen and paracetamol concentration with respectively detection limit (LOD) of 3.23×10-8 mol L-1 and 1.04×10-8 mol L-1. The applicability of the working electrode has been explored by the simultaneous electroanalysis of the ibuprofen and paracetamol in human blood samples.}, keywords = {Clay,Electrochemical behaviour,Ibuprofen,Paracetamol,Electroanalysis,Human blood}, url = {https://www.abechem.com/article_249319.html}, eprint = {https://www.abechem.com/article_249319_932746832b10e48b741ad04cfc8e59cc.pdf} }