TY - JOUR ID - 248519 TI - Development and Validation of Potentiometric Ion Selective Screen Printed Electrode for Sensitive determination of Linagliptin in pure form and in pharmaceutical formulation; Application to dissolution testing JO - Analytical and Bioanalytical Electrochemistry JA - ABEC LA - en SN - - AU - Hussien, Emad AU - Rizk, Mohamed AU - mohamed, heba AU - Elshahed, Mona AD - National Organization for Drug Control and Research (NODCAR), P.O. Box 29, Giza, Egypt AD - Analytical Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt Y1 - 2021 PY - 2021 VL - 13 IS - 3 SP - 319 EP - 339 KW - screen printed KW - potentiometric response KW - solid-state electrode KW - ion selective KW - DPP-4 inhibitor DO - N2 - A novel screen printed graphite ion-selective electrode (SPE) was prepared and characterized for determination of linagliptin (LNG) in pure form and in pharmaceutical formulation. The electrode is based on LNG-tetraphenyl borate (LNG-TPB) as ion exchanger and tricresyl phosphate (TCP) as a plasticizer. Several parameters such as the type of solvent mediator, amount of the ion-exchanger and working pH range were studied for optimal potentiometric response. Under optimal experimental conditions, the sensor exhibited a Nernstian slope of 60.10±1.02 mV/decade (n=3) over the concentration range from 1.00×10-5 to 1.00×10-2 M (r =0.9999) with LOD of 4.50×10-6 M. The electrode can be used safely over a wide pH range from 4.0 to 8.0. The electrode showed a high selectivity for LNG against common interfering substances. Fast potentiometric response was obtained within 5 seconds and remained stable for at least 60 S. The electrode was applied to the analysis of LNG in pure form and in pharmaceutical dosage form with high accuracy (98.00-102.00%) and precision (%RSD ≤2%). Our electrode has the advantages of being inexpensive, simple, sensitive, portable and disposable. UR - https://www.abechem.com/article_248519.html L1 - https://www.abechem.com/article_248519_c659923013740cc2e8f8bd368a67f6e2.pdf ER -