TY - JOUR ID - 43203 TI - Green Potentiometric Method for Determination of Triprolidine Hydrochloride and Pseudoephedrine Hydrochloride in their Different Pharmaceutical Matrices using Liquid and Solid Contact Gold Electrodes JO - Analytical and Bioanalytical Electrochemistry JA - ABEC LA - en SN - - AU - Farouk Bassuoni, Yasmine AU - essam, Hebatallah AU - Saad Elzanfaly, Eman AU - Zaazaa, Hala El-Sayed AU - Mohamed Kelani, Khadiga AD - Analytical Chemistry Department, Faculty of Pharmacy, MTI University, El Hadaba El Wosta, Mokattam 5th District, Cairo, Egypt AD - Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, 11562 Cairo, Egypt Y1 - 2020 PY - 2020 VL - 12 IS - 6 SP - 793 EP - 809 KW - Triprolidine HCl KW - Pseudoephedrine HCl KW - Ion selective electrode KW - Solid contact gold electrode KW - Ionophore DO - N2 - Factors affecting the performance of polyvinyl chloride based ion selective electrode such as using different cationic exchangers and ionophores as well as sensor fabrication procedures were recently the scope of study by several researchers. This work presents an environment friendly electro-analytical method for the determination of Triprolidine HCl (TRI) and Pseudoephedrine HCl (PSE). A comparative study was held between five suggested sensors for each drug to reach optimum response. They were developed using several exchangers as tetraphenylborate (TPB), phosphotungestate (PT) and tetrakis with different ionophores as β-cyclodextrin (β-CD) and calixarene using nitrophenyl octyl ether (NPOE) as a plasticizer. Also different strategies were applied for their membrane fabrication. Conventional sensors (3a and 3b) and solid contact gold sensors (a and b) showed the best sensitivity as well as the fastest response for determination of TRI and PSE, respectively .The two conventional sensors were composed of (PVC/TPB/β-CD/NPOE) and (PVC/PT/calixarene/NPOE) in addition to the solid contact gold sensors were composed of (TPB/β-CD/NPOE) and (PT/calixarene/NPOE). Moreover those sensors succeeded to determine TRI and PSE in their different pharmaceutical formulations. Method validation was assessed according to IUPAC recommendations. The method is considered to be a green eco-friendly technique that neither requires sample pre-treatment nor derivatization UR - https://www.abechem.com/article_43203.html L1 - https://www.abechem.com/article_43203_f246d7318426956ebd038e38c70168e0.pdf ER -