Document Type : Original Article
Laboratory of Organic and Analytical Chemistry, Sultan Moulay Slimane University, Faculty of Science and Technology, Beni Mellal, Morocco
Laboratory of Organic and Analytical Chemistry, Sultan Moulay Slimane University, Polydisciplinary Faculty, Khouribga, Morocco
In this work, we investigated the applicability of the clay-modified carbon paste electrode (CPE-clay) in the detection of paracetamol (PAR), using two electrochemical methods: differential pulse voltammetry (DPV) and cyclic voltammetry (CV) in the range between 20 and 400 mV in a Britton Robinson buffer solution (pH 7). The voltammetric technical behavior of PAR is studied where a sensitive anodic and cathodic peak has been appeared at about 0.4 V and 0.2 V (vs. Ag/AgCl/3 M KCl) successively. These peaks were recorded from the reversible redox of PAR at the CPE-clay surface. The proposed technical (DPV, CV) exhibits remarkably an electro-catalytic success for PAR redox. The current response of the catalytic peaks obtained by DPV depended linearly on the concentration of PAR in the range between 1.0 × 10-6 and 1.0 × 10-3 mol L-1 with a detection limit of 5.27 × 10-9 mol L-1. Subsequently, the relative standard deviation (RSD) at 1.0 × 10-4 mol L-1 PAR concentration was 3.8% for nine replicates. The proposed electrode has been successfully used for PAR detection in the human blood sample.