Department of Chemistry, Payame Noor University, P.O. BOX 19395-3697 Tehran, Iran
Abstract
Developing simple yet efficient sensors for drug-abuse detection is highly required from both human health and medical aspects. In this work, a glassy carbon electrode modified by a thin layer of polyL-arginine (P-L-Arg/GCE) was fabricated by electropolymerization of L-arginine monomer using cyclic voltammetry (CV) and then it was used for determination of Methadone (MET). The surface characteristics of the P-L-Arg/GCE was examined by scanning electron microscopy and electrochemical impedance spectroscopy. To study the electrochemical responses of MET on P-L-Arg/GCE and bare GCE, cyclic and differential pulse voltammetric techniques were employed. For P-L-Arg/GCE, a considerable enhancement in electrooxidation signal of MET was observed compared to bare electrode. The influence of various determinant parameters on P-L-Arg/GCE performance was studied. At optimized conditions, using DPV technique, the electrooxidation peak current was linear to MET concentration in the ranges of 0.49-2.98 µM and 2.98-11.9 µM with a detection limit of 0.32 µM. The utility of P-L-Arg/GCE was successfully validated by analyzing MET in serum and urine samples, representing its potential application for real samples analysis.
Karim-Nezhad, G., Khorablou, Z., Sadegh, B., & Mahmoudi, T. (2022). Electro-Polymerized Poly(L-Arginine) Film as An Efficient Electrode Modifier for Highly Sensitive Determination of Methadone in Real Samples. Analytical and Bioanalytical Electrochemistry, 14(8), 730-741.
MLA
Ghasem Karim-Nezhad; Zeynab Khorablou; Bayat Sadegh; Tohid Mahmoudi. "Electro-Polymerized Poly(L-Arginine) Film as An Efficient Electrode Modifier for Highly Sensitive Determination of Methadone in Real Samples". Analytical and Bioanalytical Electrochemistry, 14, 8, 2022, 730-741.
HARVARD
Karim-Nezhad, G., Khorablou, Z., Sadegh, B., Mahmoudi, T. (2022). 'Electro-Polymerized Poly(L-Arginine) Film as An Efficient Electrode Modifier for Highly Sensitive Determination of Methadone in Real Samples', Analytical and Bioanalytical Electrochemistry, 14(8), pp. 730-741.
VANCOUVER
Karim-Nezhad, G., Khorablou, Z., Sadegh, B., Mahmoudi, T. Electro-Polymerized Poly(L-Arginine) Film as An Efficient Electrode Modifier for Highly Sensitive Determination of Methadone in Real Samples. Analytical and Bioanalytical Electrochemistry, 2022; 14(8): 730-741.
)