Biomedical Application of a Novel Nanostructured-based Electrochemical Platform for Therapeutic Monitoring of an Antiepileptic Drug; Gabapentin

Authors

1 Biofuel and Renewable Energy Research Center, Department of Chemical Engineering, BabolNoshirvani University of Technology, Babol, Iran

2 Biotechnology Research Laboratory, Faculty of Chemical Engineering, BabolNoshirvani University of Technology, Babol, Iran

3 Faculty of Pharmacology, Babol University of Medical Sciences, Babol, Iran

Abstract

Herein, gold nanoparticle had been successfully synthesized through a simple, inexpensive and clean electrochemical technique. Gold nanoparticles were directly deposited on the electrode surface using an electrochemical strategy. Then, the electrochemical deposition parameters (such as applied potential and deposition time) were optimized. 1.1 V and 250 s were applied as the optimal electrodeposition potential and time in the rest of the investigations. The fabricated electrode was morphologically characterized by field emission scanning electron microscopy and energy-dispersive X-ray spectroscopy methods. Under the optimized condition, the proposed sensor demonstrated the lowest detection limit (7.04 nM) in the linear range of 0.01–1 μM obtained by differential pulse voltammetry. The electrochemical properties of fabricated modified electrode were investigated by a different techniques such as cyclic voltammetry, linear sweep voltammetry, differential pulse voltammetry, and electrochemical impedance spectroscopy. The constructed electrode also showed a negligible response from common interferences and the fabricated sensor was applied for Gabapentin analysis in pharmaceutical samples.

Keywords

References

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Analytical and Bioanalytical Electrochemistry
Volume 12, Issue 4
April 2020
Pages 536-552

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History

  • Receive Date: 20 March 2020
  • Revise Date: 20 April 2020
  • Accept Date: 17 April 2020

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