Voltammetric Determination of α-Lipoic Acid using Poly(Vanillin) Modified Platinum Electrode

Authors

1 Chemistry Department, Arts and Sciences Faculty, İnönü University, 44280, Malatya-Turkey

2 Electrical and Electronics Engineering Department,Engineering Faculty, Özyegin University, İstanbul-Turkey

Abstract

In the present study electrochemical detection of α-lipoic acid (α-LA) was carried out with a poly(Vanillin) modified platinum electrode p(VA)/PtE in Brinton Robinson buffer (BR) solution. The platinum electrode surface’s was modified with cyclic voltammetry method. The prepared Pt electrode was characterized by cyclic voltammetry in ferrocyanide and scanning electron microscopy (SEM) images. The number of cycles and scan rate effects were studied using square wave voltammetry (SWV) in BR buffer containing 1 mM α-LA. The electrochemical oxidation of α-lipoic acid on the modified Pt electrode is influenced by the pH and it is an irreversible reaction in which one electron and one proton are transferred. Electrolyte type and pH effect were studied. The anodic peak current shows a linear increase with α-LA concentrations ranging from 0.03 mM to 2.00 mM at pH 5, the detection limit being of 0.025 mM. The α-lipoic acid quantification in synthetic urine samples was made by SWV with the modified Pt electrode.

Keywords

References

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Analytical and Bioanalytical Electrochemistry
Volume 12, Issue 6
June 2020
Pages 857-869

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History

  • Receive Date: 03 May 2020
  • Revise Date: 24 June 2020
  • Accept Date: 24 June 2020

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