ISSN: ‎2008-4226, Abbreviation: Anal. Bioanal. Electrochem.

Authors

1 Chemistry Department, Arts and Sciences Faculty, İnönü University, 44280, Malatya-Turkey

2 Electrical and Electronics Engineering Department,Engineering Faculty, Özyegin University, İstanbul-Turkey

Abstract

In the present study electrochemical detection of α-lipoic acid (α-LA) was carried out with a poly(Vanillin) modified platinum electrode p(VA)/PtE in Brinton Robinson buffer (BR) solution. The platinum electrode surface’s was modified with cyclic voltammetry method. The prepared Pt electrode was characterized by cyclic voltammetry in ferrocyanide and scanning electron microscopy (SEM) images. The number of cycles and scan rate effects were studied using square wave voltammetry (SWV) in BR buffer containing 1 mM α-LA. The electrochemical oxidation of α-lipoic acid on the modified Pt electrode is influenced by the pH and it is an irreversible reaction in which one electron and one proton are transferred. Electrolyte type and pH effect were studied. The anodic peak current shows a linear increase with α-LA concentrations ranging from 0.03 mM to 2.00 mM at pH 5, the detection limit being of 0.025 mM. The α-lipoic acid quantification in synthetic urine samples was made by SWV with the modified Pt electrode.

Keywords

[1] G.P. Biewenga, G.R.M.M. Haenen, and A.A. Bast, Gen. Pharmacy 29 (1997) 315.
[2] V.D. Martins, V. Manfredini, M.C.R. Peralba, and M.S. Benfato, Clin. Nutr. 28 (2009) 192.
[3] A. Gorąca, H. Huk-Kolega, A. Piechota, P. Kleniewska, E. Ciejka, and B. Skibska, Pharm. Rep. 63 (4) (2011) 849.
[4] P. Arivazhagan, P. Juliet, and C. Panneerselvam, Pharmacol. Res. 41 (2000) 299.
[5] É. Kozlov, I. Solunina, M. Lyubareva, and M. Nadtochii, Pharm. Chem. J. 38 (2004) 642.
[6] K. Winiarska, D. Malinska, K. Szymansky, M. Dudziak, and J. Bryla, Biochimie 903 (2008) 450.
[7] A. Azimi, and M. Khalili, In: Probiotics, Prebiotics, and Synbiotics. Bioactive Foods in Health Promotion, R.R. Watson and V.R. Preedy (Ed.), Elsevier (2016) London, United Kingdom.
[8] M. Marin, C. Lete, N.B. Manolescu, and S. Lupu, J Electroanal. Chem, 729 (2014) 128.
[9] S. Sechovcová, P. Královcová, R. Kanďár, and K. Ventur, Biomed Chromatogr. 32 (2018) 4172.
[10] H.T. Chng, L.S. New, A.H. Neo, C.W. Goh, E.R. Browne, and E.C.Y. Chan, J Pharmaceut. Biomed. 51 (2010) 754.
[11] Z. Korijanac, M. Cakar, S. Tanaskovi, and T. Jovanovi, J. Serb. Chem. Soc. 72 (2007) 29.
[12] S. Satoh, M. Shindoh, J.Z. Min, T. Toyo’oka, T. Fukushima, and S. Inagaki, Anal. Chim. Acta 618 (2008) 210.
[13] B. Karakoyun, M. Yüksel, F. Ercan, C. Erzik, and B.Ç. Yeğen, Inflammation 32 (2009) 37.
[14] AI. Durrani, H. Schwartz, W. Schmid, and G. Sontag, J Pharm Biomed Anal. 45 (2007) 694.
[15] H. Li, Y. Kong, L. Chang, Z. Feng, N. Chang, J. Liu, and J. Long, Chromatographia 77 (2014) 145.
[16] L.N.S. Pereira, I.S. Silva, T.P. Araújo, A.A. Tanaka, and L. Angnes, Talanta 154 (2016) 249.
[17] S. Titretir, G. Erdogdu, and A. E. Karagözler, J Anal Chem. 61 (2006) 592.
[18] F. Karimian, G.H. Rounaghi, and M. Mohadeszadeh, J Anal Chem. 71 (2016) 1057.
[19] T. Rohani, and A. Ghaderi, J Anal Chem. 73 (2018) 277.
[20] M. Burç, Ö. Güngör, S. Titretir Duran, Anal. Bioanal. Electrochem. 12 (2020) 625.
[21] A. Paşahan, N. Ayhan, İ. Özcan, S. Titretir Duran, and S. Köytepe, Polym. Plast Technol Eng. 58 (2019) 1125.
[22] Ö. Güngör, İ. Özcan, M.A. Erdoğan, B. Ateş, and S. Köytepe, Analytical Letters 53 (2020) 228.
[23] S. Titretir Duran, J Turkish chem soc. 5 (2018) 1021.
[24] K. Ezhilarasi, V. Sudha, R. Geetha, U. Dhamodharan, R. Rama, P. Indira, V. Vijay, A.K. Hemanth Kumar, J Chromatograph Separat Techniq. 5 (2014) 1.
[25] R. Sasikumara, P. Ranganathanb, S-M. Chena, and S-P. Rwei, Sens. Actuators B, 255 (2018) 217.
[26] A. Skorupa, and S. Michalkiewicz, Int. J. Electrochem. Sci. 14 (2019) 5107.
[27] L. Mialon, A.G. Pemba, and S.A. Miller, (Communication) Green Chem. 12 (2010) 1704.
[28] M.B. Hocking, J. Chem. Educ. 74 (1997) 1055.
[29] G.S. Garbellini, R.C. Rocha-Filho, and O. Fatibello-Filho, Anal. Meth. 7 (2015) 3411.
[30] A.S. Amarasekara, B. Wiredu, and A. Razzaq, Green Chem. 14 (2012) 2395.
[31] J.G. Manjunatha, B.E. Kumara Swamy, M. Deraman, and G.P. Mamatha, Der Pharma Chemica 4 (2012) 2489.