@article { author = {Moaaz, Eman and Fayed, Ahmed and Rezk, Mamdouh}, title = {Differential Pulse Voltammetric Method for Determination of Acemetacin in Pharmaceutical Formulation using Glassy Carbon Electrode}, journal = {Analytical and Bioanalytical Electrochemistry}, volume = {13}, number = {3}, pages = {358-370}, year = {2021}, publisher = {Analytical and Bioanalytical Electrochemistry is an international scientific journal, which is published online every 3 months (since 2009), every 2 months (since 2011) and monthly (since 2018) by Center of Excellence in Electrochemistry, University of Tehran}, issn = {-}, eissn = {2008-4226}, doi = {}, abstract = {A new differential pulse voltammetric method was developed for determination of the non-steroidal anti-inflammatory drug; acemetacin. Various experimental parameters were studied, namely; electrode type, pH of the used buffer and scan rate on the reduction and oxidation peaks of acemetacin. The drug responded only to glassy carbon electrode among the studied working electrodes with higher peak current and sensitivity in the favor of the reduction side. The results also revealed that acemetacin best assayed through measuring its reduction peak current when prepared in Britton Robinson buffer solution at pH 8 when scanned at rate of 16 mV/s. The proposed method presented a bimodal calibration curve where each segment showed strong linearity. The linearity ranges were 1 - 100 µM for the lower segment and 0.1 - 3 mM for the higher one with detection limit of 0.1 µM. The proposed method was successfully applied for determination of acemetacin in its pharmaceutical dosage form.}, keywords = {Acemetacin,Glassy carbon electrode,Bimodal Calibration,Electrochemistry}, url = {https://www.abechem.com/article_248521.html}, eprint = {https://www.abechem.com/article_248521_a8c2ff0a0079edb4459d3560edd13a80.pdf} }