%0 Journal Article %T Voltammetric Determination of α-Lipoic Acid using Poly(Vanillin) Modified Platinum Electrode %J Analytical and Bioanalytical Electrochemistry %I Analytical and Bioanalytical Electrochemistry is an international scientific journal, which is published online every 3 months (since 2009), every 2 months (since 2011) and monthly (since 2018) by Center of Excellence in Electrochemistry, University of Tehran %Z - %A Titretir Duran, Serap %A Ben Ali Hassine, Chedia %A Burç, Muammer %A Güngör, Öznur %D 2020 %\ 06/01/2020 %V 12 %N 6 %P 857-869 %! Voltammetric Determination of α-Lipoic Acid using Poly(Vanillin) Modified Platinum Electrode %K square wave voltammetry %K α-lipoic acid %K Vanillin %K Platinum electrode %R %X In the present study electrochemical detection of α-lipoic acid (α-LA) was carried out with a poly(Vanillin) modified platinum electrode p(VA)/PtE in Brinton Robinson buffer (BR) solution. The platinum electrode surface’s was modified with cyclic voltammetry method. The prepared Pt electrode was characterized by cyclic voltammetry in ferrocyanide and scanning electron microscopy (SEM) images. The number of cycles and scan rate effects were studied using square wave voltammetry (SWV) in BR buffer containing 1 mM α-LA. The electrochemical oxidation of α-lipoic acid on the modified Pt electrode is influenced by the pH and it is an irreversible reaction in which one electron and one proton are transferred. Electrolyte type and pH effect were studied. The anodic peak current shows a linear increase with α-LA concentrations ranging from 0.03 mM to 2.00 mM at pH 5, the detection limit being of 0.025 mM. The α-lipoic acid quantification in synthetic urine samples was made by SWV with the modified Pt electrode. %U https://www.abechem.com/article_43207_b6ef19a7b9b3ac05773eb613afb99ed2.pdf