TY - JOUR ID - 254436 TI - Differential Pulse Voltammetric Determination of Folic Acid in the Presence of Ascorbic Acid using A Glassy Carbon Electrode Modified with Reduced Graphene Oxide JO - Analytical and Bioanalytical Electrochemistry JA - ABEC LA - en SN - - AU - Abdel-Sabour, Mohamed AU - Ahmed M. Abo-Bakr, Ahmed M. AU - Toghan, Arafat AD - Faculty of Science, Chemistry Department, South Valley University, Qena, 83523, Egypt AD - College of Science, Chemistry Department, Al Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, KSA Y1 - 2022 PY - 2022 VL - 14 IS - 8 SP - 789 EP - 805 KW - Folic acid KW - Ascorbic acid KW - Modified GC electrode KW - Reduced graphene oxide KW - Differential pulse voltammetry KW - chronoamperometry DO - N2 - Reduced graphene oxide was estimated for the modification of a glassy carbon electrode. The fabricated electrode was employed for folic acid determination in 0.1 M KCl solution (pH 14) using cyclic, linear sweep, differential pulse voltammetric and chronoamperometric techniques. The modified sensor exhibits a high electro-catalytic activity towards FA oxidation in the presence of ascorbic acid. The anodic peak current (IP) of FA increased linearly with an increase in pH (12.6–14) and scan rate (20–500 mV/s) at the ERGO/GCE. Good linearity was obtained between IP and FA concentrations (3.01–7.23 µM) with the detection (LOD) and quantification (LOQ) limits are 4.68 and 15.6 nM, respectively. Under diffusion control, the diffusion coefficient was estimated to be 2.88×10−6 cm2/s at the ERGO/GCE. The fabricated sensor gives high selectivity, good sensitivity and excellent reproducibility. Thus, the proposed method could be applied to detect FA in pharmaceutical formulations and urine samples. UR - https://www.abechem.com/article_254436.html L1 - https://www.abechem.com/article_254436_848d7a2b78d89a7c25d3fb8ffdeba125.pdf ER -