Analytical and Bioanalytical Electrochemistry is an international scientific journal, which is published online every 3 months (since 2009), every 2 months (since 2011) and monthly (since 2018) by Center of Excellence in Electrochemistry, University of Tehran Analytical and Bioanalytical Electrochemistry - 14 9 2022 09 01 Electroanalytical Techniques used in Determination of Ethinylestradiol 891 903 255011 EN Leila Hajiaghababaei Department of Chemistry, Yadegar-e-Imam Khomeini (RAH) Shahre Rey Branch, Islamic Azad University, Tehran, Iran Journal Article 2022 05 17 Ethinylestradiol (EE2) is classified as an estrogenic pharmaceutical compound. It is an agonist of the estrogen receptors and is approved for treating estrogen deficiency and osteoporosis prophylaxis in the short term when a choice of medicines is limited. EE2 is administered for the treatment of female hypogonadism and menstrual disorders. This strong estrogen is known to cause nausea, fluid retention, and thrombosis as side effects. It is, therefore, necessary to monitor EE2 levels in biological, environmental, and pharmaceutical samples. Various ultra-sensitive analytical methods were introduced during the last decades but modified electrochemical methods have great attention due to their undeniable properties. Here, all electrochemical analytical methods used for the determination of EE2 are considered and discussed. https://www.abechem.com/article_255011_b09c75b9ce7aaa975017383909a8dcfc.pdf