Analytical and Bioanalytical Electrochemistry is an international scientific journal published online by the Center of Excellence in Electrochemistry at the University of Tehran, Tehran, Iran. The journal was published quarterly from 2009 to 2011, bimonthly from 2011 to 2018, and has been published in at least eight issues per year since 2018. Analytical and Bioanalytical Electrochemistry - 15 12 2023 12 31 Determination of Acetaminophen (Paracetamol) by Tranexamic Acid Modified Glassy Carbon Electrode 1086 1097 709689 10.22034/abec.2023.709689 EN Ayşen Demir Mülazımoğlu Chemistry Department, Necmettin Erbakan University, Konya, Turkey 0000-0001-5780-3056 Nesim İslamoğlu Chemistry Department, Instutite of Science, Necmettin Erbakan University, Konya, Turkey Journal Article 2023 11 06 In this study, tranexamic acid (Txa) (in 0.1 M Sulfuric acid) modified glassy carbon electrode (GC) was tested, for the first time, as a sensor for determining the most consumed pain reliever, paracetamol (ACOP) by differential pulse voltammetry (DPV). The tranexamic acid-modified glassy carbon (rTxa/GC) electrode was characterized by a scanning electron microscope (SEM). Cyclic voltammetry (CV), linear sweep voltammetry (LSV), and electrochemical impedance spectroscopy (EIS) (in aqueous and nonaqueous solution) were used to evaluate the electrochemical performance of electrodes. The modified electrode increased the oxidation peak current of ACOP significantly in this case. The experimental results provide that rTxa/GC electrode displayed excellent electrocatalytic response to the oxidation ACOP. Additionally, the rTxa/GC electrode exhibited excellent electrocatalytic activity for the electrochemical determination of ACOP in Britton-Robinson (BR) buffer solution with pH values ranging from 2 to 12. As a result, the effective electroactive surface area of rTxa/GC electrode increased by using a BR buffer solution with pH 6. The linear range was 25 – 80 μM for ACOP with a limit of detection (LOD) of 4.7 μM and a limit of detection (LOQ) of 14.2 μM. https://www.abechem.com/article_709689_6bfe93d7c54a662dbd0e670c78233026.pdf