Development and Validation of Potentiometric Ion Selective Screen Printed Electrode for Sensitive determination of Linagliptin in pure form and in pharmaceutical formulation; Application to dissolution testing
A novel screen printed graphite ion-selective electrode (SPE) was prepared and characterized for determination of linagliptin (LNG) in pure form and in pharmaceutical formulation. The electrode is based on LNG-tetraphenyl borate (LNG-TPB) as ion exchanger and tricresyl phosphate (TCP) as a plasticizer. Several parameters such as the type of solvent mediator, amount of the ion-exchanger and working pH range were studied for optimal potentiometric response. Under optimal experimental conditions, the sensor exhibited a Nernstian slope of 60.10±1.02 mV/decade (n=3) over the concentration range from 1.00×10-5 to 1.00×10-2 M (r =0.9999) with LOD of 4.50×10-6 M. The electrode can be used safely over a wide pH range from 4.0 to 8.0. The electrode showed a high selectivity for LNG against common interfering substances. Fast potentiometric response was obtained within 5 seconds and remained stable for at least 60 S. The electrode was applied to the analysis of LNG in pure form and in pharmaceutical dosage form with high accuracy (98.00-102.00%) and precision (%RSD ≤2%). Our electrode has the advantages of being inexpensive, simple, sensitive, portable and disposable.
Hussien, E., Rizk, M., mohamed, H., & Elshahed, M. (2021). Development and Validation of Potentiometric Ion Selective Screen Printed Electrode for Sensitive determination of Linagliptin in pure form and in pharmaceutical formulation; Application to dissolution testing. Analytical and Bioanalytical Electrochemistry, 13(3), 319-339.
MLA
Emad Hussien; Mohamed Rizk; heba mohamed; Mona Elshahed. "Development and Validation of Potentiometric Ion Selective Screen Printed Electrode for Sensitive determination of Linagliptin in pure form and in pharmaceutical formulation; Application to dissolution testing". Analytical and Bioanalytical Electrochemistry, 13, 3, 2021, 319-339.
HARVARD
Hussien, E., Rizk, M., mohamed, H., Elshahed, M. (2021). 'Development and Validation of Potentiometric Ion Selective Screen Printed Electrode for Sensitive determination of Linagliptin in pure form and in pharmaceutical formulation; Application to dissolution testing', Analytical and Bioanalytical Electrochemistry, 13(3), pp. 319-339.
VANCOUVER
Hussien, E., Rizk, M., mohamed, H., Elshahed, M. Development and Validation of Potentiometric Ion Selective Screen Printed Electrode for Sensitive determination of Linagliptin in pure form and in pharmaceutical formulation; Application to dissolution testing. Analytical and Bioanalytical Electrochemistry, 2021; 13(3): 319-339.