Development of a New Sensitive Electrochemical Sensor for Dapsone Detection Using a Cobalt Metal-Organic Framework/Molecularly Imprinted Polymer Nanostructures

Document Type : Original Article


1 Department of Chemistry, Payame Noor University, P.O. Box 19395-4697,Tehran, Iran

2 Department of Chemistry, Payame Noor University, P.O. Box 19395-4697,Tehran,

3 Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran


This study reports a novel, inexpensive, and efficient approach for the synthesis of the Co metal-organic framework molecularly imprinted polymer nanoparticles (Co-MOF/MIP), which can be used as a highly selective and sensitive method for the determination of dapsone (DDS). MOFs due to high potential in the presence of porosity properties can be used in sensors based on glassy carbon electrode (GCE). The synergistic effect of the porosity network structure on glassy carbon electrode increases the power of the limits of detection (LOD). The average size of the MOFs was obtained about 17- 27nm. The first metal-organic frameworks (MOFs) with high specific surface area and high porosity were synthesized by morcellation and microwave methods. Some parameters affecting the sensor response were optimized, and a calibration curve was plotted using the differential pulse voltammetric (DPV) technique. The calibration curve of dapsone was linear in the concentration range of 0.5 up to 170 µM with y=0.0259x+0.4887 and R2= 0.9983. The linear response was obtained in the range of 0.5-170 μM of DDS concentrations with a detection limit of 0.15 µM under optimized conditions. Also, the relative standard deviation (RSD) was calculated as 1.42 % for five electrodes prepared independently.