Simultaneous Electrochemical Analysis of Ibuprofen and Paracetamol by Clay Modified Carbon Paste Electrode: Analytical Application in Human Blood

Hayat, EL Ouafy; Aamor, Mouna; Mustapha, Oubenali; Mohamed, Mbarki; EL Haimouti, Aziz; Tarik, EL Ouafy

Simultaneous Electrochemical Analysis of Ibuprofen and Paracetamol by Clay Modified Carbon Paste Electrode: Analytical Application in Human Blood

Document Type : Original Article

Authors

EL Ouafy Hayat ¹

Mouna Aamor ¹

Oubenali Mustapha ¹

Mbarki Mohamed ¹

Aziz EL Haimouti ²

EL Ouafy Tarik ²

¹ Laboratory of Engineering in Chemistry and Physics of Matter, Department of Chemistry and Environment, Faculty of Sciences and Technics, Sultan Moulay Slimane University, Beni Mellal, Morocco

² Laboratory of Engineering in Chemistry and Physics of Matter, Department of Physics and Chemistry, Polydisciplinary Faculty of Khouribga, Sultan Moulay Slimane University, Beni Mellal, Morocco

Abstract

Cyclic voltammetry and differential pulse voltammetry techniques for the simultaneous analysis of ibuprofen (IBU) and paracetamol (PCT) at carbon paste electrode modified with clay (CPE-Clay) are reported. The surface characterization of the clay was realized by zero-point charge and electrochemical methods. The electrocatalytic activity of clay toward ibuprofen electro-oxidation and paracetamol redox were reported. The kinetic parameters for ibuprofen and paracetamol electro-analysis by the modified carbon paste electrode clay-CPE were calculated. Peak ibuprofen oxidation and peaks paracetamol redox were well presented onto modified electrode clay-CPE when compared with other electrodes in the literature. Peak oxidation of the ibuprofen and peaks paracetamol redox was well presented onto modified electrode clay-CPE compared with other electrodes in the literature. The high sensitivity of the clay-CPE is measured by the DPV method showed linear variation with ibuprofen and paracetamol concentration with respectively detection limit (LOD) of 3.23×10^-8 mol L^-1 and 1.04×10^-8 mol L^-1. The applicability of the working electrode has been explored by the simultaneous electroanalysis of the ibuprofen and paracetamol in human blood samples.

Keywords

Clay

Electrochemical behaviour

Ibuprofen

Paracetamol

Electroanalysis

Human blood