Nickel Oxide Modified Carbon Paste Electrode for the cyclic voltammetric Detection of L-Tryptophan and uric acid

Document Type : Original Article


1 Dept of Industrial Chemistry, Sir M.V. Science College, Bhadravathi, Karnataka, India

2 Dept of PG studies and research in Industrial Chemistry, Kuvempu University, Jnana Sahyadri, Shankaraghatta, 577451 Shivamogga (D), Karnataka, India


The selection and development of active material is a challenge. The active sensing materials may be of any kind as whichever acts as a catalyst for sensing a particular analyte or a set of analytes.  Nickel oxide (NiO) nanoparticles are formed by using the co-precipitation method and analyzed by XRD, SEM, and EDAX techniques. The NiOMCPE was formed by using a certain amount of graphite powder, silicon oil, and different quantity of (2mg, 4mg, 6mg, and 8mg) NiO nanoparticles and further a bare carbon paste electrode was prepared by using a known amount of graphite powder and silicon oil. The NiOMCPE was used to analyze the parameters like scan rate, pH and concentration of L-tryptophan (TRP), and concentration and scan rate of uric acid (UA). Further, the modified electrodes were used for interference study and simultaneous determination of mixtures of L-tryptophan and uric acid. The same method can also be used for some other bioactive molecules.