Electrochemical Detection of Uric Acid by using NiO Nanoparticles

Document Type : Original Article


1 Dept. of Chemistry, S.V.U. College of Sciences, Sri Venkateshwara University, Tirupati-517502, Andhra Pradesh, India

2 School of Chemical Science, School of Applied Science, REVA University, Bangalore, 560064, India

3 Department of Industrial Chemistry, Kuvempu University, Shankaraghatta, 577204, Shimoga, India

4 Department of Chemistry, PES Institute of Technology and Management, Sagar Road, Guddada Arakere, Kotegangoor-577204, Shivamogga, India

5 Department of Chemistry, Dayananda Sagar College of Engineering, Shavige Malleshwara Hills, Kumaraswamy Layout, Bengaluru, 560078, India

6 Department of Physics, School of Engineering, Presidency University, Bengaluru-560064, India

7 Department of Physics, School of Applied Science, REVA University, Bangalore, 560064, India

8 Department of Chemistry, Nitte Meenakshi Institute of Technology, Bangalore-560064, India


High and low-level concentrations of uric acid (UA) lead to several diseases and physiological disorders. A simple method or sensor is required for the detection of UA. In this work, we have prepared a NiO nanoparticles/ carbon paste electrode (NiONPs/CPE) as an electrochemical sensor and applied it for the detection of UA. Electrochemical parameters such as the effect of pH, scan rate, and concentration were studied. The obtained results represent the excellent electrocatalytic activity of NiONPs/CPE with a diffusion-controlled electrode process. The electrocatalytic process was pH-dependent with a slope of 59 mV/pH. Peak current increased linearly with the increases in UA concentrations. The detection limit was found to be 0.1 mm for the linear range from 0.19 mM to 49 mM. The NiONPs/CPE electrodes exhibited good sensitivity for the detection of UA. As a result, this work is expected to be used for the development of a sensor for the detection of UA.