Development of Single Walled Carbon Nanotube-Molybdenum Disulfide Nanocomposite/poly-ethylene Glycol Modified Carbon Paste Electrode as an Electrochemical Sensor for the Investigation of Sulfadiazine in Biological Samples

Authors

Department of Chemistry, School of Chemical Science, Kuvempu University, Shankaraghatta -577451, Karnataka, India

Abstract

A rapid electrochemical analysis of sulfadiazine (SFZ) has been carried out by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) methods by employing a sensitive single walled carbon nanotube-molybdenum disulfide nanocomposite/poly ethylene glycol modified carbon paste electrode (SWCNT-MoS2/PEG/CPE). The SFZ shows anodic peak potential at 0.94 V (vs. Ag/AgCl) in 0.1 M PBS of pH 7.0. The SFZ has been examined at different scan rate from 50 to 300 mVs-1 in 0.1 M PBS of pH 7.0 and the nature of mass transfer route is diffusion-controlled process. The different pH from 5.6 to 8.0 was analyzed at SFZ and obtained the slope value 0.063 proves the equal number of electrons and protons were involved in the reaction. In DPV mode LOD of SFZ in the linear range of 2-90 μM was found to be 1.69 μM. The prepared electrode was examined by electrochemical impedance spectroscopy (EIS) using 5 mM K3[Fe(CN)6] in 0.1 M KCl. The effective surface area of SWCNT-MoS2/PEG/CPE was found to be 0.262 cm2. This method could be successfully employed to determine the concentration of SFZ in biological fluids.

Keywords

References

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Analytical and Bioanalytical Electrochemistry
Volume 12, Issue 2
February 2020
Pages 155-167

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History

  • Receive Date: 24 December 2019
  • Revise Date: 30 January 2020
  • Accept Date: 31 January 2020

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