Electrochemical Behavior of 2-Aminothiazole at Poly Glycine Modified Pencil Graphite Electrode


P.G. Department of Studies in Chemistry, Karnatak University, Dharwad-580003, India


Electro analysis of 2-Aminothiazole (2-AT) by a low cost poly Glycine modified Pencil Graphite Electrode (poly Gly/PGE) was studied using of cyclic voltammetric (CV) and differential pulse voltammetric (DPV) techniques. The optimal experimental conditions to determine 2-AT was setup by the variation of the current with scan rate, concentration and pH. Electrochemical performance of the 2-AT at poly Gly/PGE was found adsorption-controlled reaction. A plausible electro oxidation mechanism was proposed. The anodic peak current of DPV was found to be linearly proportional to the 2-AT concentrations in the range from 1.0×10-6 to 12.0×10-6 M with a detection limit 7.29×10-8 M with better selectivity and sensitivity under the optimal conditions. Quantitative analysis of 2-AT levels in urine as real sample was carried out by applying this proposed method. Moreover, some common interfering substances were used to the study of interference. The clinical and quality control laboratories can employ this method to determine 2-AT.


[1] A. Geronikaki, P. Vicini, N. Dabarakis, A. Lagunin, V. Poroikov, J. Dearden, H. Modarresi, M. Hewitt, and G. Theophilidis, Eur. J. Med. Chem. 44 (2009) 473.
[2] C. Papadopoulou, A. Geronikaki, and D. Hadjipavlou Litina, Il Farmaco. 60 (2005) 969.
[3] A. Kreutzberger, and A. Tantawy, Arch. Pharm. 314 (1981) 968.
[4] M. E. Khalifa, E. Abdel-Latif, F. A. Amer, and M. A. Metwally, Int. J. Text. Sci. 1 (2013) 62.
[5] M. Metwally, M. Khalifa, E. Attia, and F. Amer, Pol. J. Chem. Technol. 12 (2010) 1.
[6] A. Gallardo-Godoy, J. Gever, K. L. Fife, B. Michael Silber, S. B. Prusiner, and A. R. Renslo. J. Med. Chem. 54 (2011) 1010.
[7] A. Goblyos, S. N. Santiago, D. Pietra, T. Mulder-Krieger, J. von Frijtag Drabbe Kunzel, J. Brussee, and A. P. Ijzerman, Bioorg. Med. Chem. 13 (2005) 2079.
[8] P. C. Hang, and J. F. Honek, Med. Chem. Lett. 15 (2005) 1471.
[9] R. Khunt, N. Datta, and A. Parikh, Indian J. Pharm. Sci. 64 (2002) 170.
[10] P. Beuchet, M. Varache-Lembège, A. Neveu, J. M. Leger, J. Vercauteren, S. Larrouture, G. Deffieux, and A. Nuhrich, Eur. J. Med. Chem. 34 (1999) 773.
[11] A. Geronikaki, and G. Theophilidis, Eur. J. Med. Chem. 27 (1992) 709.
[12] D. S. Prasanna, C. V. Kavitha, K. Vinaya, S. R. Ranganatha, S. C. Raghavan, and K. S. Rangappa, Eur. J. Med. Chem. 45 (2010) 5331.
[13] C. A. Bolos, K. T. Papazisis, A. H. Kortsaris, S. Voyatzi, D. Zambouli, and D. A. Kyriakidis, J. Inorg. Biochem. 88 (2002) 25.
[14] O. A. Farghaly, R. S. Abdel Hameed, and A. H. Abu-Nawwas, Int. J. Electrochem. Sci. 9 (2014) 3287.
[15] R. Kalvoda, Sci. Total Environ. 37 (1984) 3.
[16] S. A. Ozkan, B. Uslu, and H. Y. Aboul-Enein, Critical Rev. Anal. Chem. 33 (2003) 155.
[17] A. Kawde, N. Baig, and M. Sajid, RSC Adv. 6 (2016) 91325.
[18] A. M. Bagoji, S. M. Patil, and S. T. Nandibewoor, Cogent Chem. 2 (2016) 1172393.
[19] V. P. Pattar, and S. T. Nandibewoor, Sens. Actuators A 250 (2016) 40.
[20] Y. Z. Zhang, G. Y. Jin, Y. L. Wang, and Z. S. Yang, Sensor 3 (2003) 443.
[21] K. V. Harisha, B. E. Kumara Swamy, and Eno E. Ebenso. J. Electanal. Chem. 823 (2018) 730.
[22] T. Thomas, R. J. Mascarenhas, B. E. Kumara Swamy, P. Martis, Z. Mekhalif, and B. S. Sherigara, Coll. Surf. B 110 (2013) 458.
[23] R. N. Goyal, Indian J. Chem. 26 (1987) 656.
[24] G. D. Christian, and W. C. Purdy, J. Electroanal. Chem. 3 (1962) 363.
[25] M. F. B. Ali, and F. A. M. Abdel-aal, RSC Adv. 9 (2019) 4325.
[26] B. Rezaei, and S. Damiri, Sens. Actuators B 134 (2008) 324.
[27] J. I. Gowda, and S. T. Nandibewoor, Electroanalysis. 28 (2016) 523.
[28] J. I. Gowda, and S. T. Nandibewoor, Ind. Eng. Chem. Res. 51 (2012) 15936.
[29] D. K. Gosser, Cyclic Voltammetry: Simulation and analysis of reaction mechanisms, VCH, New York (1993).
[30] E. Laviron, J. Electroanal. Chem. 101 (1979) 19.
[31] W. Yunhua, J. Xiaobo, and H. Shengshui, Bioelectrochem. 64 (2004) 91.
[32] V. P. Pattar, and S. T. Nandibewoor, RSC Adv. 5 (2015) 34292.