Analysis of Drug-Drug Interactions with Cyclic Voltammetry: An Overview of Relevant Theoretical Models and Recent Experimental Achievements


Faculty of Medical Sciences, Goce Delcev University, Stip, Macedonia


In this review, we focus on cyclic voltammetry as a reliable electrochemical technique to study mechanisms, kinetics and thermodynamics of various types of drug-drug interactions. While we present and discuss six theoretical models relevant to analyze drug-drug (or drug-DNA) interactions, we also give hints about recent experimental achievements in this field. In addition, we provide the readers several sets of simulated voltammograms and data in tabular form, which can be used to recognize particular mechanism of drug-drug interactions in cyclic voltammetry. Moreover, we give hints to the voltammetric procedures that allow access to kinetics and thermodynamics parameters, which are relevant to various types of drug-drug interactions. The results we present in this work can be of big help to the scientists working in the field of pharmacy, pharmacology, medicinal chemistry and bio-electrochemistry.


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Volume 12, Issue 3
March 2020
Pages 345-364
  • Receive Date: 05 February 2020
  • Revise Date: 16 March 2020
  • Accept Date: 16 March 2020