Fabrication and Validation of Novel Fexofenadine Sensor using Alizarin Red S as Ion Exchanger on PVC Matrix for Assay in Pharmaceuticals and Spiked Human Urine Samples

Document Type : Original Article


1 PG Department of Chemistry, JSS College of Arts, Commerce and Science (A Research Centre Recognized by University of Mysore), Mysuru–570 025, Karnataka, India

2 Department of Chemistry, Government First Grade College, Koratagere-572129, Karnataka, India


This study depicts the plan, optimization, validation, and utilization of a novel polyvinylchloride (PVC) lattice-assisted membrane sensor to quantify fexofenadine hydrochloride (FFH) by utilizing Alizarin Red S (ARS), β-cyclodextrin (β-CD) and nitrophenyl octyl ether (NPOE) as an ion-exchanger, ionophore, and plasticizer respectively. The PVC network-assisted FFH-ARS sensor answers in <15s with super Nernstian conduct for FFH over 2.5×10-6-1.25×10-3 mol L-1 in the pH of 2.0 to 5.5 range. The regression coefficient acquired for the alignment plot is 0.9921. The determined Nernstian slope of the line is 56.18±1.25 mV/decade. The detection limit (LOD) is viewed as 3.5×10-7 mol L-1. Validation results clarified its appropriateness to assay FFH precisely and definitively. The sensor is a decent one for robust and rugged capability with a mean RSD of 4.39%. The outcomes of the interference study confirmed the non-interference of foreign ions while measuring the potentials. Statistical comparison of the outcomes confirms the good agreement of results of the proposed analytical procedure with the reference one. The percentage of mean recovery of FFH utilizing the proposed FFH-ARS sensor was 98.56 and 95.61% for the tablets and spiked human urine respectively, and this affirmed the selectivity of the solid-state electrode for FFH.