Lanthanum Cerium Ferrite Nanoparticles for Enhancing Voltammetric Response of a Carbon Paste Electrode to Opioid Methadone

Document Type : Original Article


Center of Excellence in Electrochemistry, School of Chemistry, College of Science, University of Tehran, Tehran, Iran


Lanthanum cerium ferrite (LaCeFe2O4) nanomaterials were synthesized, characterized, and used for the modification of carbon paste electrodes, employed in the electrochemical determination of methadone. Methadone is one of the prescription opioid drugs which is widely used in addiction treatment programs. It is an electroactive material and can be measured through electrochemical methods. Simple co-precipitation method was the preparation route of nanomaterial synthesis. Cyclic voltammetry was applied for studying the modified electrode performance and square wave voltammetry was chosen as the detection technique. The limit of detection of the proposed method was 2.8 µmol L-1 of methadone. The method is able to detect methadone molecule in human plasma samples precisely.