A Review: Metal-Organic Frameworks Electrochemical Biosensors for Bioorganic Materials Detection

Sabeeh Hasan, Iman; Yakdhan Saleh, Mohanad; Aldulaimi, Ahmed Kareem Obaid; Saeed, Shakir Mahmood; Adil, Mohaned; Adhab, Ayat Hussein

doi:10.22034/abec.2024.710597

A Review: Metal-Organic Frameworks Electrochemical Biosensors for Bioorganic Materials Detection

Document Type : Review

Authors

Iman Sabeeh Hasan ¹

Mohanad Yakdhan Saleh ²

Ahmed Kareem Obaid Aldulaimi ³

Shakir Mahmood Saeed ⁴

Mohaned Adil ⁵

Ayat Hussein Adhab ¹

¹ Department of Pharmacy, Al-Zahrawi University College, Karbala, Iraq

² Department of Chemistry, College of Education for Pure Science, University of Mosul, Mosul, Iraq

³ College of Food Sciences, Al-Qasim Green University, Babylon, Iraq

⁴ Department of Pharmacy, Al-Noor University College, Nineveh, Iraq

⁵ Medical Technical College, Al-Farahidi University, Iraq

10.22034/abec.2024.710597

Abstract

Metal-organic frameworks (MOFs) have become a highly promising porous material for the detection of cancer biomarkers due to their special characteristics, such as permanent porosity and tuneable pore size. Such advantages make MOFs well-suited for use in biosensing applications. In this review, a comprehensive overview of the use of MOFs in the electrochemical detection of bioorganic materials has been provided. We begin by discussing the adjustable surface areas and porosity of MOFs, which are crucial for their applicability in biosensing. The ability to control the porosity of MOFs allows for the efficient capture and detection of specific biomarkers. Furthermore, the presence of functional sites on MOF surfaces enhances their sensitivity and selectivity towards target molecules. In the next step, we investigated different biosensors for the detection of cancer biomarkers that have used MOF to improve their performance. These biosensors utilize the unique properties of MOFs to selectively bind and detect specific biomarkers associated with different types of cancer. The high sensitivity and selectivity of these biosensors make them promising tools for early cancer diagnosis and monitoring.

Keywords

Metal-organic frameworks

Electrochemical sensor

Bioorganic materials

Biosensors

Nanomaterial

Subjects