Thiosemicarbazide Poly(paraphenylenediamine) Fastened on Modified Carbon Paste Electrode Advancing Voltammetric Determination of Dopamine and Uric Acid

Document Type : Original Article

Authors

1 Department of Chemistry, School of Applied Science & Humanities, Vignan’s University, Vadlamudi- 522212, Guntur, Andhra Pradesh, India

2 Department of Chemistry, Dravidian University, Kuppam-517426, Andhra Pradesh, India

Abstract

A film is developed on the surface of the carbon paste electrode by electro-ionic depositing of thiosemicarbazide (TSC) chemical substance and electropolymerized with paraphenylenediamine (PPD) and the modified carbon paste electrode (MCPE) was constructed at physiological pH 7.5 in PBS buffer solution. The bioactive molecules of dopamine (DP) and uric acid (UA) electro-chemical distinctiveness were studied by cyclic voltammetry method. TSC/poly(paraphenylenediamine) MCPE was used to examine DP and UA by cyclic voltammetric (CV), and differential pulse voltammetric (DPV) techniques. The addition of research constraints distressing the electrocatalytic action on MCPE such as the effect of pH, scan rate, and concentration differentiations are studied. The limit of detection of DP and UA were premeditated by CV as 1.34 µM and 4.19 µM, respectively. The modified electrode illustrated advanced sensitivity and selectivity for the synchronized determination of DP and UA, and the unclean consequence is also eradicated by this MCPE.

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Analytical and Bioanalytical Electrochemistry
Volume 16, Issue 2
February 2024
Pages 126-141

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History

  • Receive Date: 04 August 2023
  • Revise Date: 31 January 2024
  • Accept Date: 23 February 2024

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