Synthesis and Characterization of Tetraaza-Macrocyclic Complexes of MnII and NiII: Electrochemical and Antibacterial Evaluation

Vashistha, Vinod Kumar; Das, Dipak Kumar; Vallamkonda, Bhaskar; Yadav, Suman

doi:10.22034/abec.2024.715423

Synthesis and Characterization of Tetraaza-Macrocyclic Complexes of MnII and NiII: Electrochemical and Antibacterial Evaluation

Document Type : Original Article

Authors

Vinod Kumar Vashistha ¹

Dipak Kumar Das ²

Bhaskar Vallamkonda ³

Suman Yadav ⁴

¹ Department of Chemistry, University of Lucknow, Lucknow-226007, India

² Department of Chemistry, GLA University, Mathura-281406, India

³ Department of Pharmaceutical Science, VIGNAN'S Foundation for Science, Technology & Research, Vadlamudi, Guntur-522213, Andhra Pradesh, India

⁴ Department of Chemistry, Swami Shraddhanand College, University of Delhi, Delhi-110036, India

10.22034/abec.2024.715423

Abstract

Macrocyclic complexes play a crucial role in various emerging fields, including electrocatalysis, catalysis, sensor technology, pharmaceuticals, and biological applications. In this study, we synthesized a tetraaza-macrocyclic cavity capable of hosting transition metals, specifically Mn^II and Ni^II, forming the MnN₄ and NiN₄-macrocyclic complexes, respectively. Structural analyses were performed to propose the configuration of these complexes. Additionally, electrochemical studies were conducted to assess their redox potential and electron transfer kinetics. Furthermore, the biological activity of the complexes as antibacterial agents against a broad spectrum of microorganisms was investigated. The findings revealed that these complexes exhibit favorable redox properties with rapid electron transfer kinetics. The cyclic voltammogram was showed interesting results by eliminating ligand oxidation redox couple were observed as comparable in DMSO with shifting of 0.13 V peak potential in -ve peak potential range with the decreament in peak height. These results underscore the multifaceted applications of tetraaza-macrocyclic complexes in diverse fields, highlighting their importance in both fundamental research and practical biomedical interventions.

Keywords

Cyclic voltammetry

Metal complexes

biological study

MnII

NiII

Tetraaza-macrocycle

Subjects