In recent decades, there has been a continuous rise in the worldwide demand for electrochemical electrodes, driven by their established advantages such as rapidity, cost-effectiveness, user-friendly nature, and practicality in comparison to alternative electrochemical methods. However, despite these advancements, there remains a pressing need to tailor electrode preparation methods to accommodate the diverse requirements of the pharmaceutical industry. A newly developed electrochemical method was described to produce three stable probes to measure tamoxifen citrate by a coated protective layer formed from ZnO nanocomposite polymer. This modified layer was prepared by drop-casting a solution of ethaline: oxaline: water on a polymer membrane. The modified membrane exhibited potential by less than 0.22 mV for 24 days. Different analytical measurements were examined to determine the optimization proposed electrode; it was found that the addition of polymer nanocomposite metals polymer mixed with deep eutectic solvents prompted high probe efficiency used for poor solubility drugs in water. The Nernstian slope was found to be good agreement measurements in Polyvinyl Pyrrolidine (PVP) electrode around 59.71±0.60 mV/decade while other electrodes slightly decreased at 58.88±0.23 mV/decade for Poly Ethylene Glycol (PEG) and 60.20±0.15 mV/decade recorded for polyvinylchloride (PVC) electrode. Tamoxifen samples in tablet form were found to be acceptable and accurate determinations in new electrochemical technique dependent on the preparation of different nanocomposite ZnO polymer molecules, with trace added of (1.5%, 2.0%, and 2.5%) weight percentage deep eutectic solvent water mixtures (DESs) as supporting permeation during hydrophobic membranes attributed to partition and pores mechanisms helped to ion pair diffusion.