Analytical and Bioanalytical Electrochemistry

Analytical and Bioanalytical Electrochemistry

Preparation of Cephalexin Monohydrate Sensors Based on The Synthesis of CeO2 NPs for Potentiometric Determination of Cephalexin Monohydrate in Pure and Commercial Products

Document Type : Original Article

Authors
Amina Mohsen Abass 1
Fadam Muteb Abdoon 2
1 Department of Chemistry, College of Sciences, Al-Nahrain University, Baghdad, Al-Jaderia, Iraq
2 Department of Chemistry, College of Science, Tikrit University, Tikrit, Iraq
10.22034/abec.2024.717551
Abstract
Cephalexin monohydrate can be detected using potentiometric sensors made of coated wire electrodes. The Cephalexin monohydrate sensor was made of cerium oxide nanoparticles that were made using green synthesis techniques. At concentrations of 3.0×10-9-1.0×10-2 mol.L-1, an excellent response was observed with values of -54.78 and -54.76 mV.decade-1, respectively. The detection limits were between 4.0×10-2 and 9.8×10-2 mol.L-1 for CEX-PT-CeO2 NPs containing a sensor's leaves extract of Myrtus communis and CEX-PT-CeO2 NPs containing a sensor's leaves extract of Mentha. For CEX-PT-CeO2 NPs with Myrtus communis sensor leaves extract and CEX-PT-CeO2 NPs with Mentha sensor leaves extract, the PH ranged from 3.5 to 6.5, and the lifetime was 52 days. With concentrations of 8.0×10-10-1.0×10-2 mol.L-1, the CEX-PT-CeO2 NPs sensor displayed a non-Nernstian response close to -35.96 mV.decade-1, limit of detection of 4.0×10-10 mol. L-1, with a pH of 3.0-8.0. As a CEX-PT-CeO2 NPs sensor, a new coated wire electrode was developed in this study. The limit of detection, selectivity, and concentration range of the two sensors were all very high. These sensors were used to find Cephalexin monohydrate in pharmaceutical and pure products.
Keywords
Green synthesis
Potentiometric method
Detection limit
XRD analysis
Coated wire electrode

Subjects

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Analytical and Bioanalytical Electrochemistry
Volume 16, Issue 10
October 2024
Pages 943-956

  • Receive Date 09 July 2024
  • Revise Date 05 October 2024
  • Accept Date 25 October 2024