Functionalized Melissa Plant Extract-Mediated Al2O3/Fe2O3 Nanocomposite Potentiometric Sensor for Determination of Diphenhydramine

Abdoon, Fadam Muteb; Hassan, Hussein Falih; Abass, Amina Mohsen

doi:10.22034/abec.2024.718625

Functionalized Melissa Plant Extract-Mediated Al2O3/Fe2O3 Nanocomposite Potentiometric Sensor for Determination of Diphenhydramine

Document Type : Original Article

Authors

Fadam Muteb Abdoon ¹

Hussein Falih Hassan ¹

Amina Mohsen Abass ²

¹ Department of Chemistry, College of Science, Tikrit University, Tikrit, Iraq

² Department of Chemistry, College of Sciences, Al-Nahrain University, Baghdad, Al-Jaderia, Iraq

10.22034/abec.2024.718625

Abstract

A sensitive, simple, cost-effective, and eco-friendly method has been suggested for the determination of the drug diphenhydramine (DPH) in pure and pharmaceutical formulations. The method depended on the preparation of the nano-aluminum oxide (Al₂O₃ NPs) and nano-iron oxide (Fe₂O₃NPs) using the Melissa plant extract. The main purpose of this study is to determine the extent of change in electrical potential by using copper wire and aluminum wire, four electrodes were prepared. All electrodes showed Nernstian response, the best response was equal to 57.75 mv/decade for the electrode made from (sodium tetraphenylborate STPB- diphenhydramine) as an ion pair with TBP as a plasticizer and (Al₂O₃ /Fe₂O₃) NPS with the aluminum wire membrane electrode, also the concentration range was 1.0×10^-2 to 1.0×10^-8 mole.L^-1 with detection limit near to 2.07×10^-7 mole.L^-1. The value of the correlation coefficient (R²) was 0.9998. In this study, we succeeded in producing nanomaterials from green sources, with applied them in the potentiometric determination of the drug (DPH) to increase the sensitive of the preparation electrodes. These methods have become more desirable because they are characterized by ease of preparation, low cost, and do not use materials harmful to the environment.

Keywords

Green Synthesis

Diphenhydramine

Potentiometric determination

Al2O3/Fe2O3-NPs

Dried Melissa Plant

Subjects