Fabrication of Thiazole Based Heterocyclic Azo Dye Modified Carbon Paste Electrode for Detection of Dopamine: A Voltammetric Study

Paalaplara, Kusuma H; Chinnagiri, Keerthi Kumar T; Chinnagiri, Ramya Kumari T; Thippandegowdru, Raghavendra M

doi:10.22034/abec.2024.719408

Fabrication of Thiazole Based Heterocyclic Azo Dye Modified Carbon Paste Electrode for Detection of Dopamine: A Voltammetric Study

Document Type : Original Article

Authors

Kusuma H Paalaplara ¹

Keerthi kumar T Chinnagiri ¹

Ramya kumari T Chinnagiri ²

Raghavendra M Thippandegowdru ¹

¹ Department of Studies in Chemistry, Davangere University, Shivagangotri, Davangere-577007 Karnataka, India

² Department of Chemistry, D R M Science College, Davangere-577002, Karnataka, India

10.22034/abec.2024.719408

Abstract

A 5-[(4-phenyl-1, 3-thiazol-2yl) diazenyl] 1,3diazinane 2, 4,6trione (PTDDT) was synthesized from 2-amine-4-phenylethioazole. The synthesized PTDDT was characterized through using mass, UV-Visible, ¹H NMR, ¹³C NMR, elemental analysis and FT-IR. Characterized PTDDT used as a modifier for carbon paste electrode (CPE) and was used for voltammetric detection of dopamine (DA) and uric acid (UA) using phosphate buffer solution (PBS) at pH 6.6. Many different parameters were studied such as sweep rate, varied concentration, pH study. The limit of detection is 1.056 µM for DA and 0.080 µM for UA with a limit of quantification 3.521 µM for DA and 0.267 µM for UA at PTDDT/MCPE, and it also shows good repeatability and satisfactory recovery result on real samples.

Keywords

2-amine-4-phenylthioazole

Azo dye

Cyclic voltammetry

Carbon paste electrode

Differential pulse voltammetry

Subjects