A Novel Potentiometric Method for the Determination of Atenolol in Pure and Commercial Products

Katif, Hasan Amer; Hassan, Omar Salih

doi:10.22034/abec.2025.723272

A Novel Potentiometric Method for the Determination of Atenolol in Pure and Commercial Products

Document Type : Original Article

Authors

Hasan Amer Katif

Omar Salih Hassan

Department of Chemistry, College of Education for Pure Science, Tikrit University, Tikrit, Iraq

10.22034/abec.2025.723272

Abstract

To ascertain the amount of atenolol present in pharmaceutical and pure samples, two distinct kinds of ion selective electrodes were developed: coated graphite electrodes (CGE) and coated wire electrodes (CWE). At the range 6.2×10^-6-1.0×10^-2 and 4.5×10^-8-1.0×10^-2 mol.L^-1 with a slope of 52.95, and 56.23 mV/decade with a low limit of detection 1.8×10^-6 and 1.3×10^-8 mol.L^-1, the electrodes adhered to the Nernst equation for CGE and CWE electrodes, respectively. Additionally, the CWE and CGE electrodes had response times of 38 and 26 seconds and life times of 34 and 41 days, respectively. Moreover, the recommended sensors showed long-term stability and functioned after preparation with negligible variations in the potential or slope values. In this study, the ATL drug's high selectivity over a number of inorganic cations was demonstrated by the ATL sensors that were made for the drug formulation samples. The sensors being studied allow for the direct determination of ATL in specific Commercial Products.

Keywords

Atenolol

ISEs

Direct method

Nernstian response

Selectivity

Coated wire and graphite electrode

Subjects