Zinc-ion batteries have been proposed as promising alternatives for energy storage systems owing to their high safety, low cost, and environmental compatibility. Among them, V₂O₅ is considered one of the most important candidates for use as a cathode in these batteries because of its high specific capacity, multiple oxidation states, and suitable layered structure. However, challenges such as low conductivity, dissolution of vanadium in aqueous electrolytes, structural changes during the charge and discharge processes, and formation of unstable by-products have limited the performance of this material. Recently, various strategies have been introduced to overcome these problems, including interlayer insertion of cations and water molecules, metal doping, surface modification with conductive coatings, and electrolyte optimization. These modifications have led to expanded interlayer spacing, improved structural stability, enhanced ionic and electronic conductivity, and ultimately increased specific capacity and cycle life in V₂O₅-based batteries. A review of recent research suggests that structural and compositional engineering of V₂O₅ could pave the way for the development of stable and high-performance cathodes and significantly support their technological development in future energy storage applications.