Chemically Modified Carbon-based Electrodes for the Detection of Paracetamol: a Short Review

Document Type : Review


1 Laboratory of Materials Engineering for the Environment & Natural Resources, FST Errachidia, University Moulay Ismail of Meknes, BP 509 Boutalamine, 52000, Errachidia, Morocco

2 Laboratory of Physical Chemistry & Biotechnology of Biomolecules and Materials, Faculty of Sciences and Techniques of Mohammedia (FSTM), Morocco

3 Laboratory of Solar Energy and Environment, Faculty of Sciences, Mohammed V University, Rabat, B.P. 1014, Morocco

4 Laboratory of Water and Environment, Department of Chemistry, Faculty of Sciences, University Chouaïb Doukkali, PO. Box 20, El Jadida 24000, Morocco


Paracetamol (PCM) drug used in the treatment of pain, fever and headache, and it is considered safely for human use subjects. It has been found that the overdose and the chronic use of PCM produces toxic effects of environmental and immediate allergic hypersensitivity. Therefore, it is essential to develop sufficiently sensitive and simple sensors for precise determination of PCM. Chemically modified carbon-based electrodes have been widely used in this approach. This review is focused on the use of various chemically modified carbon-based electrodes such as glassy carbon, carbon paste, carbon screen-printed, graphene paste, and boron doped diamond electrodes in the electrochemical detection of PCM. Finally, we have briefly summarized the recent chemically modified carbon-based electrodes for the determination of PCM using articles encompassing 2018 until June 2020 and the efficiency of sensors are compared in terms of linear range, limits of detection and other proprieties can affect PCM detection as pH, medium, potential oxidation.